منابع مشابه
The cellular response to vascular endothelial growth factors requires co-ordinated signal transduction, trafficking and proteolysis
VEGFs (vascular endothelial growth factors) are a family of conserved disulfide-linked soluble secretory glycoproteins found in higher eukaryotes. VEGFs mediate a wide range of responses in different tissues including metabolic homoeostasis, cell proliferation, migration and tubulogenesis. Such responses are initiated by VEGF binding to soluble and membrane-bound VEGFRs (VEGF receptor tyrosine ...
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Malignant cells are characterized by high mitogenic activity, disorganized growth, and the ability to invade surrounding normal tissues in vivo. Invasion and metastasis require the release of cells from the restrictive effects of the extracellular matrix, the degradation of basement membranes, the intrusion of malignant cells into connective tissues, and their spread through circulation or lymp...
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In this issue of Thrombosis and Haemostasis a collection of review articles and original contributions have been published coinciding with the “17th International Congress on Fibrinolysis and Proteolysis” to be held in Melbourne, Australia, at the end of March 2004. It is widely acknowledged that the field of fibrinolysis and proteolysis has enormously expanded since the early discoveries of, f...
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BACKGROUND Cellular contractility, essential for cell movement and proliferation, is regulated by microtubules, RhoA and actomyosin. The RhoA dependent kinase ROCK ensures the phosphorylation of the regulatory Myosin II Light Chain (MLC) Ser19, thereby activating actomyosin contractions. Microtubules are upstream inhibitors of contractility and their depolymerization or depletion cause cells to...
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Crocin, the main constituent of saffron (Crocus sativus L.), is a natural carotenoid which is known for its antioxidant activity. Liver as the organ that metabolizes many chemicals is one of the first position that is at risk of environmental pollutants. It is clear that compounds that exhibit antioxidant properties, scavenging of free radicals and inhibition of lipid peroxidation are expected ...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 1992
ISSN: 1880-8808,0915-7441
DOI: 10.2491/jjsth.3.95